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LGI3 antibody (Center)

LGI3 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500158
  • Target See all LGI3 Antibodies
    LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))
    Binding Specificity
    • 15
    • 7
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 19
    • 18
    • 13
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 2
    Rabbit
    Clonality
    • 28
    • 1
    Polyclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LGI3 antibody is un-conjugated
    Application
    • 29
    • 13
    • 13
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects LGI3 at center. It will recognize both isoforms. The antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    LGI3 antibody was raised against a 12 amino acid peptide from near the center of human LGI3.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    LGI3 (Leucine-Rich Repeat LGI Family, Member 3 (LGI3))
    Alternative Name
    LGI3 (LGI3 Products)
    Synonyms
    si:ch211-198o12.2 antibody, LGIL4 antibody, AI841179 antibody, AW049851 antibody, leucine rich repeat LGI family member 3 antibody, leucine-rich repeat LGI family, member 3 antibody, LGI3 antibody, lgi3 antibody, Lgi3 antibody
    Background
    The leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Ab) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Ab. Two isoforms of LGI3 are known to exist.Synonyms: LGI1-like protein 4, LGI3, LGIL4, Leucine-rich glioma-inactivated protein 3, Leucine-rich repeat LGI family member 3
    Gene ID
    203190
    UniProt
    Q8N145
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