DHX58 antibody (N-Term)

Catalog No. ABIN500166

Product Details anti-DHX58 Antibody

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHX58 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects DHX58 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: LGP2 antibody was raised against a 14 amino acid peptide from near the amino terminus of human LGP2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for DHX58

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Alternative Name: DHX58 (DHX58 Products)

Synonyms: MGC82787 antibody, DHX58 antibody, lgp2 antibody, D11LGP2 antibody, D11lgp2e antibody, LGP2 antibody, RLR-3 antibody, B430001I08Rik antibody, D11Lgp2e antibody, LPG2 antibody, Lgp2 antibody, RGD1310093 antibody, DEXH-box helicase 58 L homeolog antibody, DExH-box helicase 58 antibody, probable ATP-dependent RNA helicase DHX58 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody, DEXH-box helicase 58 antibody, dhx58.L antibody, DHX58 antibody, dhx58 antibody, LOC100566102 antibody, Dhx58 antibody

Background: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.Synonyms: ATP-dependent RNA helicase DHX58, ATP-dependent helicase LGP2, D11LGP2E, DHX58, LGP2, Protein D11Lgp2 homolog

Gene ID: 79132

UniProt: Q96C10