LRFN2
Reactivity: Rat
WB, IF (cc), IF (p)
Host: Rabbit
Polyclonal
Alexa Fluor 750
Application Notes
ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target
LRFN2
(Leucine Rich Repeat and Fibronectin Type III Domain Containing 2 (LRFN2))
FIGLER2 antibody, KIAA1246 antibody, RP11-535K1.2 antibody, SALM1 antibody, 5730420O05Rik antibody, mKIAA1246 antibody, Salm1 antibody, leucine rich repeat and fibronectin type III domain containing 2 antibody, LRFN2 antibody, Lrfn2 antibody
Background
LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN2 are known to exist.Synonyms: KIAA1246, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, SALM1