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Transportin 1 antibody (N-Term)

TNPO1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500230
  • Target See all Transportin 1 (TNPO1) Antibodies
    Transportin 1 (TNPO1)
    Binding Specificity
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 40
    • 21
    • 18
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 37
    • 4
    • 1
    Rabbit
    Clonality
    • 38
    • 4
    Polyclonal
    Conjugate
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Transportin 1 antibody is un-conjugated
    Application
    • 40
    • 19
    • 17
    • 14
    • 13
    • 6
    • 5
    • 4
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects MIP1 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    MAPKAP1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human MAPKAP1.
    Isotype
    IgG
    Top Product
    Discover our top product TNPO1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Transportin 1 (TNPO1)
    Alternative Name
    MIP1 (TNPO1 Products)
    Synonyms
    IPO2 antibody, KPNB2 antibody, MIP antibody, MIP1 antibody, TRN antibody, TNPO1 antibody, AU021749 antibody, D13Ertd688e antibody, Kpnb2 antibody, ATTRN1 antibody, F12A24.13 antibody, F12A24_13 antibody, TRANSPORTIN 1 antibody, transportin 1 antibody, DKFZp469O204 antibody, transportin 1 antibody, transportin-1 antibody, transportin 1 S homeolog antibody, TNPO1 antibody, LOC738932 antibody, tnpo1 antibody, Tnpo1 antibody, tnpo1.S antibody, TRN1 antibody
    Background
    MAPKAP1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.Synonyms: MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, SAPK-interacting protein 1, SIN1, Stress-activated map kinase-interacting protein 1, TORC2 subunit MAPKAP1, Target of rapamycin complex 2 subunit MAPKAP1, mSIN1
    Gene ID
    79109
    NCBI Accession
    NP_001006618
    UniProt
    Q9BPZ7
    Pathways
    PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
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