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Survivin antibody (C-Term)

BIRC5 Reactivity: Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500292
  • Target See all Survivin (BIRC5) Antibodies
    Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
    Binding Specificity
    • 20
    • 16
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 147
    • 60
    • 51
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 111
    • 43
    • 1
    • 1
    Rabbit
    Clonality
    • 109
    • 47
    Polyclonal
    Conjugate
    • 84
    • 15
    • 10
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Survivin antibody is un-conjugated
    Application
    • 118
    • 55
    • 43
    • 35
    • 26
    • 24
    • 23
    • 23
    • 14
    • 13
    • 7
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects IAP4 / BIRC5 at C-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Peptide affinity chromatography
    Immunogen
    Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.
    Isotype
    IgG
    Top Product
    Discover our top product BIRC5 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 to 2 μg/mL, an approximate 17 kDa band can be detected. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
    Alternative Name
    IAP4 / BIRC5 (BIRC5 Products)
    Synonyms
    AP14 antibody, API4 antibody, EPR-1 antibody, AAC-11 antibody, Api4 antibody, TIAP antibody, survivin40 antibody, bir5a antibody, survivin antibody, BIR1 antibody, Su2 antibody, XBIR1 antibody, XSurvivin1 antibody, Xsvv1 antibody, api4 antibody, bir1-A antibody, epr-1 antibody, svv1 antibody, xSurvivin antibody, xsurv antibody, Su1 antibody, birc5.2 antibody, svv2 antibody, xSurvivin2 antibody, bir5b antibody, SIX antibody, birc5.2-a antibody, birc5.2-b antibody, baculoviral IAP repeat containing 5 antibody, baculoviral IAP repeat-containing 5 antibody, baculoviral IAP repeat containing 5a antibody, baculoviral IAP repeat-containing 5, gene 1 L homeolog antibody, baculoviral IAP repeat containing 5 L homeolog antibody, baculoviral IAP repeat containing 5b antibody, baculoviral IAP repeat containing 5 S homeolog antibody, BIRC5 antibody, Birc5 antibody, birc5a antibody, birc5.1.L antibody, birc5.2.L antibody, birc5b antibody, birc5.2.S antibody
    Background
    Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
    Gene ID
    11799
    UniProt
    O70201
    Pathways
    Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
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