MTBP (AA 122-139), (Middle Region) antibody

Details for Product No. ABIN500294
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Antigen
Synonyms MDM2BP, AI429604
Epitope
AA 122-139, Middle Region
(11), (4), (4), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(42), (13), (11), (11), (11), (11), (11), (1)
Host
Rabbit
(39), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(33), (12), (11), (9), (7), (3), (3), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN500294
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Immunogen MTBP antibody was raised against a synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids (7).
Isotype IgG
Specificity This antibody detects MTBP at center. Species Reactivity: Tested: Human
Purification Peptide affinity chromatography
Background The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6) and MTBP (7), were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53 (7). MTBP is expressed in a variety of normal tissues (7).
Alternate names: Mdm2, Mdm2-binding protein, hMTBP
Gene ID 27085
NCBI Accession NP_071328
UniProt Q96DY7
Research Area Cancer, Cell Cycle
Application Notes ELISA. Western blot. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).

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