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MYD88 antibody (AA 233-248)

MYD88 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500300
  • Target See all MYD88 Antibodies
    MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
    Binding Specificity
    • 15
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 233-248
    Reactivity
    • 97
    • 62
    • 50
    • 16
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 91
    • 11
    • 2
    Rabbit
    Clonality
    • 83
    • 21
    Polyclonal
    Conjugate
    • 64
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYD88 antibody is un-conjugated
    Application
    • 85
    • 32
    • 22
    • 17
    • 16
    • 14
    • 13
    • 13
    • 11
    • 10
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects MYD88 at center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Peptide affinity chromatography
    Immunogen
    MyD88 antibody was raised against a peptide corresponding to amino acids 233 to 248 of human MyD88, which differ from those of mouse by two amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MYD88 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1: 500 - 1: 1000 dilution, whole cell lysate from Jurkat cells can be used aspositive control and an approximately 35 kDa band can be detected. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
    Alternative Name
    MYD88 (MYD88 Products)
    Synonyms
    MYD88D antibody, XMyD88 antibody, myd88d antibody, MGC84928 antibody, CG2078 antibody, DMMYD88 antibody, DmMyD88 antibody, DmMyd88 antibody, Dmel\\CG2078 antibody, EP(2)2535 antibody, Kra antibody, LD20892 antibody, MYD88 antibody, MyD88 antibody, Myd88F antibody, dMyD88 antibody, dMyd88 antibody, kra antibody, myd88 antibody, zgc:103541 antibody, GB12344 antibody, NV10640 antibody, myd88-a antibody, myd88-b antibody, myeloid differentiation primary response 88 antibody, myeloid differentiation primary response 88 S homeolog antibody, myeloid differentiation primary response gene 88 antibody, CG2078 gene product from transcript CG2078-RB antibody, myeloid differentiation primary response protein MyD88-A antibody, myeloid differentiation primary response protein MyD88 antibody, myeloid differentiation factor 88 antibody, myeloid differentiation primary response 88 L homeolog antibody, MYD88 antibody, myd88.S antibody, Myd88 antibody, myd88 antibody, LOC413194 antibody, LOC100118553 antibody, LOC575153 antibody, myd88.L antibody
    Background
    The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
    Gene ID
    4615
    UniProt
    Q99836
    Pathways
    NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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