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NLRP2 antibody (NLR Family, Pyrin Domain Containing 2) (C-Term)

Details for Product anti-NLRP2 Antibody No. ABIN500312, Supplier: Log in to see
Antigen
  • CLR19.9
  • E330007A02Rik
  • NALP2
  • Nalp2
  • nbs
  • NBS1
  • Nbs1
  • nbs1
  • NLRP2
  • PAN1
  • PYPAF2
Epitope
C-Term
41
17
14
12
5
5
4
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
140
59
26
4
3
3
2
2
1
1
Host
Rabbit
99
25
23
3
Clonality
Polyclonal
Conjugate
This NLRP2 antibody is un-conjugated
5
5
5
4
4
4
3
3
3
3
3
3
3
3
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
137
55
47
37
30
29
24
9
3
2
2
1
1
Supplier
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Immunogen NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.
Isotype IgG
Specificity This antibody detects NALP2.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name NALP2 (NLRP2 Antibody Abstract)
Background NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD) (2). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1Β-processing activity and is thought to function as a modulator of NF-ΚB and procaspase-1 activation in macrophages (2,3). It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) (4). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.Synonyms: LRR and PYD domains-containing protein 2, NACHT, NBS1, NLRP2, PAN1, PYPAF2
Gene ID 55655
NCBI Accession NP_060322
UniProt Q9NX02
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLRP2 antibody (NLR Family, Pyrin Domain Containing 2) (C-Term) (ABIN500312) Western blot analysis of NALP2 in PC-3 cell lysate with this product at (A) 1 and (B)...
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).