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NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) antibody

Details for Product No. ABIN500314
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Antigen
Synonyms CIAS1, Nalp3, avp, cias1, nalp3, pypaf1, agtavprl, AGTAVPRL, AII, AVP, C1orf7, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, AII/AVP, Cias1, Mmig1, Pypaf1
Epitope
N-Term
(22), (8), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(93), (36), (30), (16), (5), (2)
Host
Rabbit
(58), (19), (17), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(63), (39), (21), (20), (13), (7), (6), (6), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN500314
401.50 $
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Immunogen A 16 amino acid peptide from near the amino terminus of Human NALP3.
Isotype IgG
Purification Paptide Affinity Chromatography
Alternative Name NALP3
Background NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1b, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-kB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
Alternate names: C1orf7, CIAS1, LRR and PYD domains-containing protein 3, NACHT, NLRP3, PYPAF1
Gene ID 114548
NCBI Accession NP_899632
UniProt Q96P20
Application Notes ELISA. Western blot: 1 - 2 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Chamaillard, Girardin, Viala et al.: "Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation." in: Cellular microbiology, Vol. 5, Issue 9, pp. 581-92, 2003 (PubMed).

OConnor, Harton, Zhu et al.: "Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 12, pp. 6329-33, 2003 (PubMed).

Agostini, Martinon, Burns et al.: "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." in: Immunity, Vol. 20, Issue 3, pp. 319-25, 2004 (PubMed).

Kanneganti, Ozören, Body-Malapel et al.: "Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3." in: Nature, Vol. 440, Issue 7081, pp. 233-6, 2006 (PubMed).

Mohamad, Surikumaran, Raoov et al.: "Conventional Study on Novel Dicationic Ionic Liquid Inclusion with β-Cyclodextrin." in: International journal of molecular sciences, Vol. 12, Issue 9, pp. 6329-45, 2011 (PubMed).

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