You are viewing an incomplete version of our website. Please click to reload the website as full version.

NLRP3 antibody (NLR Family, Pyrin Domain Containing 3) (N-Term)

Details for Product anti-NLRP3 Antibody No. ABIN500314, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms CIAS1, Nalp3, avp, cias1, nalp3, pypaf1, agtavprl, AGTAVPRL, AII, AVP, C1orf7, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, AII/AVP, Cias1, Mmig1, Pypaf1
(37), (30), (17), (14), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Human, Mouse (Murine)
(164), (34), (29), (6), (5), (4), (2), (1), (1)
(85), (53), (30), (3)
This NLRP3 antibody is un-conjugated
(6), (6), (6), (5), (5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(106), (87), (31), (27), (17), (13), (11), (8), (7), (4), (3), (2), (1)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen A 16 amino acid peptide from near the amino terminus of Human NALP3.
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Paptide Affinity Chromatography
Alternative Name NALP3 (NLRP3 Antibody Abstract)
Background NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1b, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-kB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).Synonyms: C1orf7, CIAS1, LRR and PYD domains-containing protein 3, NACHT, NLRP3, PYPAF1
Gene ID 114548
NCBI Accession NP_899632
UniProt Q96P20
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Immunofluorescence (IF) image for anti-NLRP3 antibody (NLR Family, Pyrin Domain Containing 3) (N-Term) (ABIN500314) Immunofluorescence of NALP3 in K562 cells with NALP3 antibody at 20 μg/ml.
Western Blotting (WB) image for anti-NLRP3 antibody (NLR Family, Pyrin Domain Containing 3) (N-Term) (ABIN500314) Western blot analysis of NALP3 in K562 cell lysate with NALP3 antibody at 1 μg/ml (A)...
Background publications Mohamad, Surikumaran, Raoov et al.: "Conventional Study on Novel Dicationic Ionic Liquid Inclusion with β-Cyclodextrin." in: International journal of molecular sciences, Vol. 12, Issue 9, pp. 6329-45, 2011 (PubMed).

Kanneganti, Ozören, Body-Malapel et al.: "Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3." in: Nature, Vol. 440, Issue 7081, pp. 233-6, 2006 (PubMed).

Agostini, Martinon, Burns et al.: "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." in: Immunity, Vol. 20, Issue 3, pp. 319-25, 2004 (PubMed).

OConnor, Harton, Zhu et al.: "Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 12, pp. 6329-33, 2003 (PubMed).

Chamaillard, Girardin, Viala et al.: "Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation." in: Cellular microbiology, Vol. 5, Issue 9, pp. 581-92, 2003 (PubMed).

Catalog No. ABIN500314
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)