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HTRA2 antibody (C-Term)

HTRA2 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500413
  • Target See all HTRA2 Antibodies
    HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
    Binding Specificity
    • 15
    • 15
    • 9
    • 9
    • 8
    • 7
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 113
    • 71
    • 67
    • 2
    • 1
    Human
    Host
    • 101
    • 13
    Rabbit
    Clonality
    • 90
    • 24
    Polyclonal
    Conjugate
    • 45
    • 10
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This HTRA2 antibody is un-conjugated
    Application
    • 73
    • 44
    • 30
    • 26
    • 26
    • 20
    • 8
    • 8
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects HTRA2 / PRSS25.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Ion exchange chromatography
    Immunogen
    OMI antibody was raised against a peptide corresponding to 15 amino acids near the C- terminus of human OMI.
    Isotype
    IgG
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    Discover our top product HTRA2 Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
    Alternative Name
    HTRA2 / PRSS25 (HTRA2 Products)
    Synonyms
    CG8464 antibody, DmHtrA2 antibody, Dmel\\CG8464 antibody, HtrA2/Omi antibody, Omi antibody, dOmi antibody, domi antibody, htrA2 antibody, omi antibody, HTRA2 antibody, PRSS25 antibody, OMI antibody, PARK13 antibody, AI481710 antibody, Prss25 antibody, mnd2 antibody, HTRA2-related serine protease antibody, HtrA serine peptidase 2 antibody, HtrA2 antibody, HTRA2 antibody, htra2 antibody, Htra2 antibody
    Background
    Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication (1). Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases (reviewed in 2). The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs (reviewed in 3). Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs (4). Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis (5).Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2
    Gene ID
    27429
    UniProt
    O43464
    Pathways
    Positive Regulation of Endopeptidase Activity
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