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PRDM16 antibody (C-Term)

PRDM16 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500533
  • Target See all PRDM16 Antibodies
    PRDM16 (PR Domain Containing 16 (PRDM16))
    Binding Specificity
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 16
    • 11
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 14
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 16
    • 2
    Polyclonal
    Conjugate
    • 14
    • 2
    • 1
    • 1
    This PRDM16 antibody is un-conjugated
    Application
    • 12
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat
    Purification
    Peptide Affinity Chromatography
    Immunogen
    PRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of Human PRDM16.
    Isotype
    IgG
    Top Product
    Discover our top product PRDM16 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections. Positive Control: Rat Brain Tissue Lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Upon receipt store the antibody (in aliquots) at -20 °C.
  • Target
    PRDM16 (PR Domain Containing 16 (PRDM16))
    Alternative Name
    PRDM16 (PRDM16 Products)
    Synonyms
    PRDM16 antibody, wu:fc09g08 antibody, MEL1 antibody, PFM13 antibody, 5730557K01Rik antibody, C130091E20 antibody, csp1 antibody, mKIAA1675 antibody, mel1 antibody, PR/SET domain 16 antibody, PR domain containing 16 antibody, PRDM16 antibody, prdm16 antibody, Prdm16 antibody
    Background
    PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.Synonyms: KIAA1675, MDS1/EVI1-like gene 1, MEL1, PFM13, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1
    Gene ID
    63976
    UniProt
    Q9HAZ2
    Pathways
    Stem Cell Maintenance, Brown Fat Cell Differentiation
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