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CBLN1 antibody (Center)

CBLN1 Reactivity: Human, Rat, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500537
  • Target See all CBLN1 Antibodies
    CBLN1 (Cerebellin 1 Precursor (CBLN1))
    Binding Specificity
    • 6
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 17
    • 16
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 17
    • 1
    Rabbit
    Clonality
    • 17
    • 1
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBLN1 antibody is un-conjugated
    Application
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Precerebellin at center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    Precerebellin antibody was raised against a 15 amino acid peptide from the middle of human precerebellin.
    Isotype
    IgG
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    Discover our top product CBLN1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    CBLN1 (Cerebellin 1 Precursor (CBLN1))
    Alternative Name
    Cerebellin-1 (CBLN1 Products)
    Synonyms
    cbln1 antibody, zgc:92807 antibody, CBLN1 antibody, MGC145915 antibody, AI323299 antibody, cerebellin 3 precursor antibody, cerebellin 1 precursor antibody, cerebellin 1 precursor L homeolog antibody, cerebellin 1 precursor protein antibody, cbln3 antibody, cbln1 antibody, cbln1.L antibody, CBLN1 antibody, Cbln1 antibody
    Background
    Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q (1). Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway (2), and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (3). The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus (4). Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated (5).Synonyms: CBLN1, Precerebellin
    Gene ID
    869
    NCBI Accession
    NP_004343
    UniProt
    P23435
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