HRIP antibody, RIP antibody, 2400006N03Rik antibody, RP23-83I13.5 antibody, Rip antibody, RGD1308492 antibody, RPAIN antibody, MGC153251 antibody, rpain antibody, xripalpha antibody, rip-B antibody, RPA interacting protein antibody, RPA interacting protein S homeolog antibody, RPA interacting protein L homeolog antibody, RPAIN antibody, Rpain antibody, rpain antibody, rpain.S antibody, rpain.L antibody
Background
Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import (2). Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism.Synonyms: RPA-interacting protein