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SCO1 antibody (Center)

SCO1 Reactivity: Human, Rat, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500686
  • Target See all SCO1 Antibodies
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Binding Specificity
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 15
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 12
    • 3
    Rabbit
    Clonality
    • 15
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This SCO1 antibody is un-conjugated
    Application
    • 10
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects SCO1 / SCOD1 (both isoforms). It has no cross-reactivity to SCO2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    SCO1 antibody was raised against a 14 amino acid peptide from near the center of human SCO1.
    Isotype
    IgG
    Top Product
    Discover our top product SCO1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Alternative Name
    SCO1 / SCOD1 (SCO1 Products)
    Synonyms
    SCOD1 antibody, 2610001C07Rik antibody, D11Bwg1310e antibody, SCO1 antibody, RGD1559538 antibody, SCO1, cytochrome c oxidase assembly protein antibody, SCO1 cytochrome c oxidase assembly protein antibody, SCO1 antibody, Sco1 antibody, sco1 antibody
    Background
    Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist.Synonyms: Protein SCO1 homolog mitochondrial
    Gene ID
    6341
    UniProt
    O75880
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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