Seasonal H1N1 Hemagglutinin antibody

Details for Product No. ABIN500696
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Antigen
Reactivity
Avian Influenza Virus H1N1
(2)
Host
Rabbit
(2)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500696
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Immunogen Hemagglutinin antibody was raised against a synthetic peptide from the Hemagglutinin protein. .Remarks: The peptide sequence is unique from the peptide sequence for product AP30770PU-N and AP30772PU-N.
Isotype IgG
Specificity This antibody detects Seasonal H1N1 Hemagglutinin. It will not cross-react with peptide corresponding to the swine-origin H1N1 influenza Hemagglutinin.
Purification Peptide affinity chromatography
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin (4). The distinct antigenic properties of the new swine virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups (5). This antibody is specific for the seasonal H1N1 influenza Hemagglutinin and will not recognize the corresponding Hemagglutinin sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).
Alternate names: Common flu H1, HA, Seasonal Influenza A Hemagglutinin, flu H1
UniProt B0VX44
Application Notes ELISA: detects 2 ng of free peptide at 1 μg/ml. Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Thompson, Shay, Weintraub et al.: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA : the journal of the American Medical Association, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

Butler: "Swine flu goes global." in: Nature, Vol. 458, Issue 7242, pp. 1082-3, 2009 (PubMed).

Dawood, Jain, Finelli et al.: "Emergence of a novel swine-origin influenza A (H1N1) virus in humans." in: The New England journal of medicine, Vol. 360, Issue 25, pp. 2605-15, 2009 (PubMed).

Morens, Taubenberger, Fauci: "The persistent legacy of the 1918 influenza virus." in: The New England journal of medicine, Vol. 361, Issue 3, pp. 225-9, 2009 (PubMed).

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