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Influenza A Virus H1N1 Neuraminidase antibody

Details for Product No. ABIN500700, Supplier: Log in to see
Antigen
Reactivity
Avian Influenza Virus H1N1
9
5
5
3
1
Host
Rabbit
12
11
Clonality
Polyclonal
Conjugate
Un-conjugated
1
Application
Enzyme Immunoassay (EIA)
12
11
Options
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Immunogen Neuraminidase antibody was raised against a synthetic peptide from the seasonal influenza (H1N1) Neuraminidase protein.
Isotype IgG
Purification Peptide affinity chromatography
Alternative Name Seasonal H1N1 Neuraminidase
Target Type Virus
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin (4). The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups (5). This antibody is specific for Neuraminidase from the seasonal influenza (H1N1) and will not recognize the corresponding Neuraminidase sequence from the swine-origin influenza virus (A/California/14/2009 (H1N1)).
UniProt B1AGS8
Application Notes ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Enzyme Immunoassay (EIA) image for anti-Influenza A Virus H1N1 Neuraminidase antibody (ABIN500700) ELISA results using AP30773PU-N at 1 μg/ml and the blocking and corresponding peptide...
Product cited in: Dawood, Jain, Finelli, Shaw, Lindstrom, Garten, Gubareva, Xu, Bridges, Uyeki: "Emergence of a novel swine-origin influenza A (H1N1) virus in humans." in: The New England journal of medicine, Vol. 360, Issue 25, pp. 2605-15, 2009 (PubMed).

Butler: "Swine flu goes global." in: Nature, Vol. 458, Issue 7242, pp. 1082-3, 2009 (PubMed).

Morens, Taubenberger, Fauci: "The persistent legacy of the 1918 influenza virus." in: The New England journal of medicine, Vol. 361, Issue 3, pp. 225-9, 2009 (PubMed).

Background publications Thompson, Shay, Weintraub, Brammer, Cox, Anderson, Fukuda: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).