Seasonal H1N1 Neuraminidase antibody

Details for Product No. ABIN500700
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Antigen
Reactivity
Avian Influenza Virus H1N1
Host
Rabbit
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500700
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Immunogen Neuraminidase antibody was raised against a synthetic peptide from the seasonal influenza (H1N1) Neuraminidase protein.
Isotype IgG
Purification Peptide affinity chromatography
Target Type Virus
Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin (4). The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups (5). This antibody is specific for Neuraminidase from the seasonal influenza (H1N1) and will not recognize the corresponding Neuraminidase sequence from the swine-origin influenza virus (A/California/14/2009 (H1N1)).
UniProt B1AGS8
Application Notes ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Background publications Thompson, Shay, Weintraub et al.: "Mortality associated with influenza and respiratory syncytial virus in the United States." in: JAMA : the journal of the American Medical Association, Vol. 289, Issue 2, pp. 179-86, 2003 (PubMed).

Butler: "Swine flu goes global." in: Nature, Vol. 458, Issue 7242, pp. 1082-3, 2009 (PubMed).

Dawood, Jain, Finelli et al.: "Emergence of a novel swine-origin influenza A (H1N1) virus in humans." in: The New England journal of medicine, Vol. 360, Issue 25, pp. 2605-15, 2009 (PubMed).

Morens, Taubenberger, Fauci: "The persistent legacy of the 1918 influenza virus." in: The New England journal of medicine, Vol. 361, Issue 3, pp. 225-9, 2009 (PubMed).

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