SRPX antibody (N-Term)

Catalog No. ABIN500807

Product Details anti-SRPX Antibody

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: SRPX1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human SRPX1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.25 - 0.5 μg/mL. Immunhistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SRPX

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Alternative Name: SRPX / ETX1 (SRPX Products)

Synonyms: DRS antibody, ETX1 antibody, SRPX1 antibody, drs antibody, drs-1 antibody, drs-2 antibody, mDRS-1 antibody, mDRS-2 antibody, Drs antibody, sushi repeat containing protein, X-linked antibody, sushi-repeat-containing protein antibody, sushi-repeat-containing protein, X-linked antibody, SRPX antibody, Srpx antibody

Background: SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.Synonyms: Sushi repeat-containing protein SRPX

Gene ID: 8406

NCBI Accession: NP_006298