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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody

Details for Product No. ABIN500837, Supplier: Log in to see
Antigen
  • CG4494
  • Dm0342
  • DmSUMO-1
  • DmSmt3
  • Dmel\\CG4494
  • Dmsmt3
  • SMT3
  • SUMO
  • Smt3
  • Sumo
  • anon-EST:Posey240
  • dSmt3
  • dsmt3
  • l(2)04493
  • l(2)SH0182
  • l(2)SH2 0182
  • sumo
  • SUMO1
  • sumo-1
  • sumo1
  • 4921531N22Rik
  • AI789753
  • AU040360
  • DAP-1
  • Gkap
  • DAP1
  • GMP1
  • OFC10
  • PIC1
  • SENP2
  • SMT3C
  • SMT3H3
  • UBL1
  • ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1
  • ATSUMO1
  • F10M23.180
  • F10M23_180
  • SMALL UBIQUITIN-LIKE MODIFIER 1
  • SUM1
  • SUMO 1
  • small ubiquitin-like modifier 1
  • pigSUMO1
  • SENTRIN
  • SMTP3
  • SUMO-1
  • Smt3C
  • Ubl1
  • hm:zeh0670
  • wu:fb74c02
  • wu:fd12c02
  • zgc:65934
  • zgc:85634
Epitope
N-Term
47
21
14
14
13
7
6
5
5
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
249
84
82
4
3
3
2
2
1
1
1
Host
Rabbit
201
47
4
2
1
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
14
13
12
7
7
7
3
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
194
108
101
68
52
36
33
28
15
9
3
2
1
Supplier
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Immunogen Sumo antibody was raised against a 14 amino acid peptide from near the amino terminus of human sumo.
Isotype IgG
Specificity This antibody detects SUMO1. It will only recognize isoform 1.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name SUMO1 (SUMO1 Antibody Abstract)
Background The sumo family of proteins is related both structurally and functionally to ubiquitin in that they are post-translationally attached to the e-amino group of a lysine residue of the substrate protein. This sumoylation plays a number of roles in DNA replication and repair, protein targeting to various subnuclear structures, and the regulation of numerous cellular processes including the inflammatory response in mammalian cells. Sumo was initially identified as a covalent modification of RanGAP1 in studies on nuclear import in mammalian cells. More recently, sumo has been shown to be involved in the regulation of transcription factors, possibly by enhancing their interactions with co-repressors. Sumo is also thought to play some role in the modulation of ubiquitin-mediated degradation of proteins by acting as an inhibitor. At least four different isoforms of sumo are known to exist.Synonyms: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin-related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1
Gene ID 7341
Research Area Signaling, Proteases, DNA/RNA
Pathways
Application Notes ELISA. Immunohistochemistry on paraffin sections. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody (ABIN500837) Immunocytochemistry of Sumo in HL60 cells with this product at 5 μg/ml.
Western Blotting (WB) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody (ABIN500837) Western blot analysis of sumo in HL-60 cell lysate with this product at (A) 0.5, (B) ...
Background publications Dohmen: "SUMO protein modification." in: Biochimica et biophysica acta, Vol. 1695, Issue 1-3, pp. 113-31, 2004 (PubMed).

Desterro, Rodriguez, Hay: "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation." in: Molecular cell, Vol. 2, Issue 2, pp. 233-9, 1998 (PubMed).

Matunis, Coutavas, Blobel: "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex." in: The Journal of cell biology, Vol. 135, Issue 6 Pt 1, pp. 1457-70, 1997 (PubMed).