GPR124 antibody (Center)

Catalog No. ABIN500897

Product Details anti-GPR124 Antibody

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Binding Specificity: Center

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR124 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.

Cross-Reactivity (Details): Species reactivity (tested):Human, rat

Purification: Peptide affinity chromatography

Immunogen: TEM5 antibody was raised against a 14 amino acid peptide near the center of human TEM5.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for GPR124

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Alternative Name: GPR124 / TEM5 (GPR124 Products)

Synonyms: TEM5 antibody, 8430414O08Rik antibody, 9530074E10Rik antibody, Tem5 antibody, mKIAA1531 antibody, MGC69043 antibody, si:dkey-208c22.2 antibody, GPR124 antibody, adhesion G protein-coupled receptor A2 antibody, adhesion G protein-coupled receptor A2 L homeolog antibody, G-protein coupled receptor 124 antibody, ADGRA2 antibody, Adgra2 antibody, adgra2.L antibody, adgra2 antibody, LOC616111 antibody

Background: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.Synonyms: G-protein coupled receptor 124, KIAA1531, Tumor endothelial marker 5

Gene ID: 25960

UniProt: Q96PE1