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TREX2 antibody (C-Term)

Trex2 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN501038
  • Target See all TREX2 (Trex2) Antibodies
    TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))
    Binding Specificity
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 22
    • 1
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TREX2 antibody is un-conjugated
    Application
    • 13
    • 13
    • 7
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TREX2. The antibody will not cross-react with the related protein TREX1.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    TREX2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.
    Isotype
    IgG
    Top Product
    Discover our top product Trex2 Primary Antibody
  • Application Notes
    ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TREX2 (Trex2) (three Prime Repair Exonuclease 2 (Trex2))
    Alternative Name
    TREX2 (Trex2 Products)
    Synonyms
    RGD1562245 antibody, three prime repair exonuclease 2 antibody, TREX2 antibody, Trex2 antibody
    Background
    TREX2 is one of two major human 3\' to 5\' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2
    Gene ID
    11219
    UniProt
    Q9BQ50
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