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TRIM5 antibody (C-Term, Isoform alpha)

TRIM5 Reactivity: Human, Rhesus Monkey WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN501054
  • Target See all TRIM5 Antibodies
    TRIM5 (Tripartite Motif Containing 5 (TRIM5))
    Binding Specificity
    • 12
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term, Isoform alpha
    Reactivity
    • 45
    • 4
    • 4
    • 1
    Human, Rhesus Monkey
    Host
    • 39
    • 4
    • 2
    Rabbit
    Clonality
    • 40
    • 4
    Polyclonal
    Conjugate
    • 31
    • 4
    • 3
    • 3
    • 2
    • 2
    This TRIM5 antibody is un-conjugated
    Application
    • 39
    • 28
    • 10
    • 10
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TRIM5 / RNF88 at C-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):Rhesus monkeySpecies reactivity (tested):Human
    Purification
    Paptide affinity chromatography
    Immunogen
    TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of rhesus monkey TRIM5 alpha.
    Isotype
    IgG
    Top Product
    Discover our top product TRIM5 Primary Antibody
  • Application Notes
    ELISA. Immunoflourescence. Western blot: 1 to 2 μg/mL. A band at approximately 55 kDa can be detected.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TRIM5 (Tripartite Motif Containing 5 (TRIM5))
    Alternative Name
    TRIM5 / RNF88 (TRIM5 Products)
    Synonyms
    TRIM5 antibody, RNF88 antibody, TRIM5alpha antibody, EG667823 antibody, Gm8833 antibody, RGD1304579 antibody, tripartite motif containing 5 antibody, tripartite motif-containing 5 antibody, TRIM5 antibody, Trim5 antibody
    Background
    TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has six alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission (3).Synonyms: RING finger protein 88, Tripartite motif-containing protein 5
    Gene ID
    85363
    NCBI Accession
    NP_149023
    Pathways
    Activation of Innate immune Response
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