UNG antibody (N-Term)

Catalog No. ABIN501108

Product Details anti-UNG Antibody

Target: UNG (Uracil-DNA Glycosylase (UNG))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Uracil-DNA glycosylase (UNG) at N-term. The antibody will not cross-react with UNG2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography

Immunogen: UNG1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human UNG1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Abstract: UNG Products

Synonyms: DGU antibody, HIGM4 antibody, HIGM5 antibody, UDG antibody, UNG1 antibody, UNG15 antibody, UNG2 antibody, ung antibody, zgc:56102 antibody, PSPTO4236 antibody, BA5648 antibody, ECK2578 antibody, JW2564 antibody, An02g14790 antibody, AO090001000732 antibody, DDBDRAFT_0204444 antibody, DDBDRAFT_0214910 antibody, DDB_0204444 antibody, DDB_0214910 antibody, uracil-DNA glycosylase antibody, uracil DNA glycosylase antibody, uracil DNA glycosylase a antibody, uracil-DNA glycosylase Ung antibody, uracil-DNA-glycosylase antibody, uracil DNA glycosylase L homeolog antibody, uracil glycosylase antibody, temporal expression: early antibody, ung antibody, ung2 antibody, Ung antibody, UNG antibody, unga antibody, STY2840 antibody, ung.L antibody, ANI_1_3358024 antibody, AOR_1_1318164 antibody, uglA antibody, Arnit_2731 antibody, D4R antibody

Target Type: Viral Protein

Background: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner.Synonyms: DGU, UDG, UNG1, UNG15

Gene ID: 7374

NCBI Accession: NP_003353

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response