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XBP1 antibody (X-Box Binding Protein 1) (N-Term)

Details for Product anti-XBP1 Antibody No. ABIN501132, Supplier: Log in to see
Antigen
  • treb5
  • xXBP1
  • xbp2
  • XBP1P1
  • XBPP1
  • xbp1
  • TREB5
  • XBP-1
  • XBP2
  • D11Ertd39e
  • TREB-5
  • HTF
  • cb918
  • id:ibd1195
  • trebf
  • wu:fb02h05
  • wu:fb63f10
  • xbp1a
  • xbp1b
Epitope
N-Term
37
27
18
15
13
13
12
12
9
6
5
4
3
3
2
2
1
1
Reactivity
Human, Mouse (Murine)
167
74
48
4
4
3
1
1
1
1
1
Host
Rabbit
111
49
19
5
Clonality
Polyclonal
Conjugate
This XBP1 antibody is un-conjugated
6
6
5
5
5
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
162
93
39
28
23
18
11
9
9
7
3
2
1
1
1
Supplier
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Immunogen XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography
Alternative Name XBP1 / TREB5 (XBP1 Antibody Abstract)
Background X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
Gene ID 7494
Application Notes ELISA. Western blot. Immunohistochemistry on paraffin sections: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Immunofluorescence (IF) image for anti-XBP1 antibody (X-Box Binding Protein 1) (N-Term) (ABIN501132) Immunocytochemistry of XBP-1 in HepG2 cells with this product at 10 μg/ml.
Western Blotting (WB) image for anti-XBP1 antibody (X-Box Binding Protein 1) (N-Term) (ABIN501132) Western blot analysis of XBP-1 in HepG2 cell lysate with this product at (A) 0.5, (B)...
Background publications Yoshida, Matsui, Yamamoto et al.: "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor." in: Cell, Vol. 107, Issue 7, pp. 881-91, 2002 (PubMed).