gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (Middle Region) antibody

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Antigen
Synonyms ECA4, EJM, EJM5, zgc:153566, Gabra-1
Epitope
Middle Region
(18), (16), (10), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(59), (59), (57), (11), (6), (4), (3), (2), (1), (1)
Host
Rabbit
(80), (25), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(93), (22), (21), (18), (18), (13), (12), (10), (3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human GABRA1
Sequence YDLLGQTVDS GIVQSSTGEY VVMTTHFHLK RKIGYFVIQT YLPCIMTVIL
Predicted Reactivity Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, African clawed frog : 90 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against GABRA1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name GABRA1 (GABRA1 Antibody Abstract)
Background GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.
Molecular Weight 52 kDa
Gene ID 2554
NCBI Accession NM_000806, NP_000797
UniProt P14867
Research Area Receptors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 456 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (Middle Region) antibody (ABIN501360) WB Suggested Anti-GABRA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Yang, Sonner: "The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors." in: Anesthesia and analgesia, Vol. 106, Issue 3, pp. 838-45, table of contents, 2008 (PubMed).

Catalog No. ABIN501360
$289.00
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