Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) (N-Term) antibody

Details for Product No. ABIN501366
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Antigen
Synonyms CIR, cir, xcir, GIRK4, KATP1, KIR3.4, LQT13, Kir3.4
Epitope
N-Term
(10), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Pig (Porcine), Human, Chicken
(40), (24), (23), (18), (18), (17), (1), (1), (1), (1)
Host
Rabbit
(38), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (14), (11), (6), (5), (3), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN501366
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human KCNJ5
Sequence AGDSRNAMNQ DMEIGVTPWD PKKIPKQARD YVPIATDRTR LLAEGKKPRQ
Predicted Reactivity Human : 100 %, Bovine : 90 %, Chicken : 90 %, Dog : 90 %, Horse : 90 %, Mouse : 90 %, Rat : 90 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against KCNJ5. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNJ5
Background Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ5 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ5, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. Sequence Note: The sequence U52154.1 is a chimeric mRNA clone. Only the potassium inwardly-rectifying channel, subfamily J, member 5 region was propagated into this RefSeq record.
Molecular Weight 48 kDa
Gene ID 3762
NCBI Accession NM_000890, NP_000881
UniProt P48544
Research Area Cardiovascular, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 419 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Ji, Foo, ORoak et al.: "Rare independent mutations in renal salt handling genes contribute to blood pressure variation." in: Nature genetics, Vol. 40, Issue 5, pp. 592-9, 2008 (PubMed).

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