Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4) (Middle Region) antibody

Details for Product No. ABIN501374
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Antigen
Synonyms AI850292, KSHIIIC, Kcr2-4, Kv3.4, C1orf30, HKSHIIIC, KV3.4
Epitope
Middle Region
(22), (11), (9), (8), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(47), (41), (24), (12), (12), (12), (2), (1)
Host
Rabbit
(45), (26)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(61), (43), (29), (22), (22), (10), (10), (7), (6), (2), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN501374
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human KCNC4
Sequence NIDRNVTEIL RVGNITSVHF RREVETEPIL TYIEGVCVLW FTLEFLVRIV
Predicted Reactivity Human : 100 %, Guinea pig : 90 %, Mouse : 90 %, Rat : 90 %, Bovine : 80 %, Horse : 80 %, Pig : 80 %
Characteristics This is a rabbit polyclonal antibody against KCNC4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNC4
Background KCNC4 is part of the Shaker gene family of Drosophila. It encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. KCNC4 belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 64 kDa
Gene ID 3749
NCBI Accession NM_153763, NP_720198
Research Area Neurology, Alzheimer's Disease
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 582 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4) (Middle Region) antibody WB Suggested Anti-KCNC4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4) (Middle Region) antibody (2) anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4 (KCNC4) (Middle Region) antibody (Image 2)
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Validation Images
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