KCNA10 antibody (N-Term)

Catalog No. ABIN501379

Product Details anti-KCNA10 Antibody

Target: KCNA10 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 (KCNA10))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: DVCGWKEMEV ALVNFDNSDE IQEEPGYATD FDSTSPKGRP GGSSFSNGKI

Predicted Reactivity: Cow: 92%, Dog: 79%, Guinea Pig: 93%, Horse: 85%, Human: 100%, Mouse: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against KCNA10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KCNA10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 511 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KCNA10

Target: KCNA10 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 10 (KCNA10))

Alternative Name: KCNA10 (KCNA10 Products)

Synonyms: cKv1.2 antibody, Kcn1 antibody, Kv1.8 antibody, Gm1962 antibody, Kcna8 antibody, potassium voltage-gated channel subfamily A member 10 antibody, potassium voltage-gated channel, shaker-related subfamily, member 10 antibody, KCNA10 antibody, Kcna10 antibody

Background: KCNA10 is a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.
Alias Symbols: Kcn1, Kv1.8
Protein Interaction Partner: POMP,
Protein Size: 511

Molecular Weight: 58 kDa

Gene ID: 3744

NCBI Accession: NM_005549, NP_005540

UniProt: Q16322