Adenosine Deaminase, RNA-Specific (ADAR) (N-Term) antibody

Details for Product No. ABIN501587
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Antigen
Synonyms
red1, drada, wu:fc22a02, adar1, dsRAD, dsRAD-1, ADAR, ADAR1, CG12598, Dmel\\CG12598, EG:BACN35H14.1, adar, adr, cg12598, dADAR, dAdar, hypnos-2, NV18763, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K8 ... show more
red1, drada, wu:fc22a02, adar1, dsRAD, dsRAD-1, ADAR, ADAR1, CG12598, Dmel\\CG12598, EG:BACN35H14.1, adar, adr, cg12598, dADAR, dAdar, hypnos-2, NV18763, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136, AV242451, Adar1, mZaADAR show less
Epitope
N-Term
(19), (13), (3), (2), (1), (1), (1)
Reactivity
Human
(51), (28), (26), (3)
Host
Rabbit
(49), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(25), (20), (16), (13), (9), (8), (3), (3), (3), (2), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN501587
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ADAR
Sequence GEGKATTAHD LSGKLGTPKK EINRVLYSLA KKGKLQKEAG TPPLWKIAVS
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against ADAR. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ADAR
Background ADAR is responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Molecular Weight 136 kDa
Gene ID 103
NCBI Accession NM_001111, NP_001102
UniProt P55265
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1226 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Product cited in: Pan, Ye, Franco et al.: "Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study." in: Journal of affective disorders, Vol. 109, Issue 1-2, pp. 75-82, 2008 (PubMed).

Background publications Zhang, Liu, Jiang et al.: "Six novel mutations of the ADAR1 gene in Chinese patients with dyschromatosis symmetrica hereditaria." in: Journal of dermatological science, Vol. 50, Issue 2, pp. 109-14, 2008 (PubMed).

Validation Images
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