Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody

Details for Product No. ABIN501698
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Antigen
Synonyms NRF1, LOC100220087, AA408798, AW212678, LCR-F1, Lcrf1, TCF-11, TCF11, ALPHA-PAL, SC:BZ3C13.1, SC:bZ3C13.2, ube2h, IBR/F, Nfe2l1_retired, C87038, D6Ertd415e, alpha-pal, nrf-1
Epitope
N-Term
(23), (15), (12), (6), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(80), (42), (32), (1), (1), (1), (1)
Host
Rabbit
(77), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(75), (43), (15), (11), (10), (4), (3), (3), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human NRF1
Sequence MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 90 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against NRF1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name NRF1 (NRF1 Antibody Abstract)
Background NRF1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
Molecular Weight 53 kDa
Gene ID 4899
NCBI Accession NM_005011, NP_005002
UniProt Q16656
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 503 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody WB Suggested Anti-NRF1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
anti-Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody (2) anti-Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody (Image 2)
anti-Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody (3) WB Suggested Anti-NRF1
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 ...
Background publications Ramachandran, Yu, Gulick: "Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 11935-46, 2008 (PubMed).

Validation Images
Catalog No. ABIN501698
289.00 $
Plus shipping costs $45.00
Quantity
Price
50 μg
289.00 $

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