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Details for Product No. ABIN501698

Nuclear Respiratory Factor 1 (NRF1) (N-Term) antibody

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Antigen
Synonyms ALPHA-PAL, C87038, D6Ertd415e, ube2h, SC:BZ3C13.1, SC:bZ3C13.2, Nfe2l1_retired, IBR/F, alpha-pal, nrf-1, AA408798, AW212678, LCR-F1, Lcrf1, NRF1, TCF-11, TCF11, LOC100220087
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Xenopus laevis, Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN501698
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-NRF1 antibody: synthetic peptide directed towards the N terminal of human NRF1
Sequence MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSA DEDSPSSPED
Predicted Reactivity Bovine : 100%, Chicken : 100%, Dog : 100%, Guinea pig : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Rabbit : 100%, Rat : 100%, Zebrafish : 92%, African clawed frog : 85%
Characteristics This is a rabbit polyclonal antibody against NRF1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name NRF1
Background NRF1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
Molecular Weight 53kDa
Gene ID 4899
NCBI Accession NP_005002, NM_005011
UniProt Q16656
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-NRF1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Ramachandran, Yu, Gulick: "Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 11935-46, 2008 (PubMed).

Alternatives for antigen "Nuclear Respiratory Factor 1 (NRF1)", type "Antibodies"
Hosts (42), (6)
Reactivities (42), (33), (26), (2), (2), (2), (1), (1), (1)
Applications (39), (27), (14), (10), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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