SIM2 antibody (N-Term)

Catalog No. ABIN501700

Product Details anti-SIM2 Antibody

Target: SIM2 (Single-Minded Homolog 2 (SIM2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against SIM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SIM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 667 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SIM2 antibody (ABIN501700)

Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

Target Details for SIM2

Target: SIM2 (Single-Minded Homolog 2 (SIM2))

Alternative Name: SIM2 (SIM2 Products)

Synonyms: Xsim2 antibody, sim2-A antibody, xSim antibody, HMC13F06 antibody, HMC29C01 antibody, SIM antibody, bHLHe15 antibody, single-minded family bHLH transcription factor 2 S homeolog antibody, single-minded family bHLH transcription factor 2 antibody, single-minded homolog 2 (Drosophila) antibody, sim2.S antibody, sim2 antibody, SIM2 antibody, Sim2 antibody

Background: SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on t
Alias Symbols: MGC119447, SIM, bHLHe15, HMC13F06, HMC29C01
Protein Interaction Partner: Dlg4, HSP90AA1, ARIH1, UBC, PARK2, ARNT, ARNT2, EPO,
Protein Size: 667

Molecular Weight: 73 kDa

Gene ID: 6493

NCBI Accession: NM_005069, NP_005060

UniProt: Q14190