2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2) (Middle Region) antibody

Details for Product No. ABIN502029
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Antigen
Synonyms Oasl11
Epitope
Middle Region
(6), (5), (4), (1), (1), (1)
Reactivity
Pig (Porcine), Cow (Bovine), Dog (Canine), Human
(30), (13), (13), (12), (1), (1)
Host
Rabbit
(28), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(14), (10), (9), (8), (3)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502029
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Immunogen Synthetic peptide directed towards the middle region of human OAS2
Sequence AKGTALKTGS DADLVVFHNS LKSYTSQKNE RHKIVKEIHE QLKAFWREKE
Predicted Reactivity Human : 100 %, Pig : 100 %, Bovine : 90 %, Dog : 90 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against OAS2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name OAS2
Background OAS2 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
Molecular Weight 82 kDa
Gene ID 4939
NCBI Accession NP_058197, NM_016817
UniProt P29728
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 719 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Scherer, Muzny, Buhay et al.: "The finished DNA sequence of human chromosome 12." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).

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