Pulmonary Surfactant-Associated Protein B (Middle Region) antibody

Details for Product No. ABIN502105
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Antigen
Synonyms AI562151, SF-B, SP-B, Sftp-3, Sftp3, PSP-B, SFTB3, SFTP3, SMDP1, Sp-b, SFTPB
Epitope
Middle Region
(11), (8), (4), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Rat (Rattus), Mouse (Murine), Dog (Canine), Pig (Porcine), Cow (Bovine), Human
(52), (19), (17), (4), (3), (1)
Host
Rabbit
(52), (19)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(46), (28), (20), (13), (10), (4), (4), (4), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502105
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human SFTPB
Sequence PGALQARPGP HTQDLSEQQF PIPLPYCWLC RALIKRIQAM IPKGALAVAV
Predicted Reactivity Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Rat : 100 %, Mouse : 90 %, Pig : 80 %
Characteristics This is a rabbit polyclonal antibody against SFTPB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SFTPB
Background SFTPB is the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins. See also SFTPA1, SFTPC, and SFTPD. The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).
Molecular Weight 42 kDa
Gene ID 6439
NCBI Accession NM_000542, NP_000533
UniProt B2RC55
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 381 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Pulmonary Surfactant-Associated Protein B (Middle Region) antibody WB Suggested Anti-SFTPB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 721_B cell lysate
Background publications Garmany, Wambach, Heins et al.: "Population and disease-based prevalence of the common mutations associated with surfactant deficiency." in: Pediatric research, Vol. 63, Issue 6, pp. 645-9, 2008 (PubMed).

Validation Images
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