Troponin T2, Cardiac (TNNT2) (N-Term) antibody

Details for Product No. ABIN502162
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Antigen
Synonyms CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, CTTG, Ctt, RATCTTG, Tnnt3, CT3, Tnt, tnnt2
Epitope
N-Term
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Pig (Porcine), Xenopus laevis, Human, Chicken
(141), (28), (24), (15), (14), (7), (7), (5), (5), (3), (2), (2), (1)
Host
Rabbit
(132), (44), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (2), (1)
Application
Western Blotting (WB)
(130), (101), (39), (20), (16), (15), (14), (12), (12), (8), (7), (5), (5), (4), (3), (2), (2), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502162
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TNNT2
Sequence ESKPKPRSFM PNLVPPKIPD GERVDFDDIH RKRMEKDLNE LQALIEAHFE
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, Zebrafish : 100 %, African clawed frog : 90 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against TNNT2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TNNT2
Background TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in the gene encoding TNNT2 have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.
Molecular Weight 35 kDa
Gene ID 7139
NCBI Accession NM_000364, NP_000355
UniProt A2TDB9
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 295 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Klaassen, Probst, Oechslin et al.: "Mutations in sarcomere protein genes in left ventricular noncompaction." in: Circulation, Vol. 117, Issue 22, pp. 2893-901, 2008 (PubMed).

Validation Images
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