Glutaryl-CoA Dehydrogenase (GCDH) (N-Term) antibody

Details for Product No. ABIN502403
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Antigen
Synonyms ACAD5, GCD, zgc:56505, zgc:77704, 9030411L18, AI266902, D17825
Epitope
N-Term
(12), (9), (8), (3), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(39), (16), (15), (2), (2)
Host
Rabbit
(38), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(31), (16), (12), (10), (6), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502403
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Immunogen Synthetic peptide directed towards the N terminal of human GCDH
Sequence SLVMHPIYAY GSEEQRQKYL PQLAKGELLG CFGLTEPNSG SDPSSMETRA
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %, Horse : 90 %, Pig : 80 %, African clawed frog : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against GCDH. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name GCDH
Background GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.Alternatively spliced transcript variants encoding different isoforms have been identified.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Molecular Weight 43 kDa
Gene ID 2639
NCBI Accession NP_000150, NM_000159
UniProt Q92947
Research Area Signaling, Metabolism, Organelles
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 438 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Glutaryl-CoA Dehydrogenase (GCDH) (N-Term) antibody WB Suggested Anti-GCDH Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate
Background publications Rao, Albro, Dwyer et al.: "Kinetic mechanism of glutaryl-CoA dehydrogenase." in: Biochemistry, Vol. 45, Issue 51, pp. 15853-61, 2007 (PubMed).

Validation Images
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