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Details for Product No. ABIN502530

Ectodysplasin A (EDA) (Middle Region) antibody

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Antigen
Synonyms ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED, si:ch73-223d24.5, Ed1, Eda-A1, Eda-A2, Ta, tabby, RGD1563178
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Zebrafish (Danio rerio), Cow (Bovine), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN502530
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-EDA antibody: synthetic peptide directed towards the middle region of human EDA
Sequence GPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQG SAIQVKNDLS
Predicted Reactivity Bovine : 100%, Chicken : 100%, Dog : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rat : 100%, Rabbit : 92%, Zebrafish : 92%
Characteristics This is a rabbit polyclonal antibody against EDA. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name EDA
Background EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Molecular Weight 41kDa
Gene ID 1896
NCBI Accession NP_001005609, NM_001005609
UniProt Q92838
Research Area Lineage Markers
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-EDA antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Product cited in: Zhao, Watt, Battle et al.: "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice." in: Developmental biology, Vol. 317, Issue 2, pp. 614-9, 2008 (PubMed).

Background publications Zhao, Hua, Zhao et al.: "Three novel mutations of the EDA gene in Chinese patients with X-linked hypohidrotic ectodermal dysplasia." in: The British journal of dermatology, Vol. 158, Issue 3, pp. 614-7, 2008 (PubMed).

Alternatives for antigen "Ectodysplasin A (EDA)", type "Antibodies"
Hosts (46), (1)
Reactivities (45), (32), (32), (30), (18), (12), (1)
Applications (22), (20), (18), (13), (10), (3)
Conjugates (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (2), (1), (1)
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