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NR5A1 antibody (Middle Region)

NR5A1 Reactivity: Human, Rat, Guinea Pig, Dog, Horse, Rabbit, Cow, Sheep, Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN502654
  • Target See all NR5A1 Antibodies
    NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
    Binding Specificity
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 46
    • 20
    • 20
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Guinea Pig, Dog, Horse, Rabbit, Cow, Sheep, Pig
    Host
    • 46
    • 3
    Rabbit
    Clonality
    • 45
    • 4
    Polyclonal
    Conjugate
    • 32
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR5A1 antibody is un-conjugated
    Application
    • 34
    • 21
    • 17
    • 13
    • 10
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    SLHGPEPKGL AAGPPAGPLG DFGAPALPMA VPGAHGPLAG YLYPAFPGRA
    Predicted Reactivity
    Cow: 79%, Dog: 86%, Guinea Pig: 91%, Horse: 86%, Human: 100%, Pig: 92%, Rabbit: 79%, Rat: 86%, Sheep: 79%
    Characteristics
    This is a rabbit polyclonal antibody against NR5A1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NR5A1
    Top Product
    Discover our top product NR5A1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 461 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Derebecka-Holysz, Lehmann, Holysz, Trzeciak: "SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells." in: Molecular and cellular biochemistry, Vol. 307, Issue 1-2, pp. 65-71, (2007) (PubMed).

  • Target
    NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
    Alternative Name
    NR5A1 (NR5A1 Products)
    Synonyms
    AD4BP antibody, ELP antibody, FTZ1 antibody, FTZF1 antibody, POF7 antibody, SF-1 antibody, SF1 antibody, SPGF8 antibody, SRXY3 antibody, Ad4BP antibody, ELP-3 antibody, Ftz-F1 antibody, Ftzf1 antibody, Ad4BP/SF-1 antibody, Ad4bp antibody, Sf-1 antibody, NR5A1 antibody, sf-1 antibody, elp antibody, sf1 antibody, ftz1 antibody, ad4bp antibody, ftzf1 antibody, SF-1/Ad4BP antibody, SI:zC167P9.2 antibody, ff1d antibody, nr5a2l antibody, nuclear receptor subfamily 5 group A member 1 antibody, nuclear receptor subfamily 5, group A, member 1 antibody, nuclear receptor subfamily 5 group A member 1 L homeolog antibody, nuclear receptor subfamily 6 group A member 1 antibody, nuclear receptor subfamily 5, group A, member 1b antibody, NR5A1 antibody, Nr5a1 antibody, nr5a1.L antibody, nr5a1 antibody, NR6A1 antibody, nr5a1b antibody
    Background
    NR5A1 is an important regulator of steroidogeneisis which is present in human skin and its appendages. It plays a role in regulating p450scc expression with TReP-132 and CBP/p300. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: AD4BP, ELP, FTZ1, FTZF1, SF-1, SF1, POF7, SPGF8, SRXY3
    Protein Interaction Partner: NCK2, NR0B1, RAD54L2, THOC2, ALYREF, EIF4A3, DDX39B, UBC, BARD1, ELAVL1, TCF7L2, CTNNB1, CREBBP, CXXC1, PNRC2, SOX8, PIAS1, ZNF653, TRERF1, EDF1, GATA4, GTF2B, SOX2, SOX9, TBX19, NCOA1, NRIP1, PITX1, SMARCD3, PROX1, AR, SP1, NFYA, MAPK1, JUN, NFKB2,
    Protein Size: 461
    Molecular Weight
    52 kDa
    Gene ID
    2516
    NCBI Accession
    NM_004959, NP_004950
    UniProt
    Q13285
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Maintenance of Protein Location
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