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Lamin B1 antibody (LMNB1) (Middle Region)

Details for Product anti-LMNB1 Antibody No. ABIN502713, Supplier: Login to see New
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Antigen
Synonyms MGC52550, Lamin-L(I), lamin-b, lmn, lmn2, lmnb, LMNB1, ADLD, LMN, LMN2, LMNB, fc06g01, wu:fc06g01
Alternatives
Epitope
Middle Region
(20), (10), (9), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(123), (51), (47), (9), (7), (6), (5), (4), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(77), (37), (19)
Clonality
Polyclonal
Conjugate
This Lamin B1 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(125), (59), (38), (28), (25), (20), (16), (12), (10), (5), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human LMNB1
Blocking Peptide Blocking peptide for this product available: ABIN979358
Sequence EEVAQRSTVF KTTIPEEEEE EEEAAGVVVE EELFHQQGTP RASNRSCAIM
Predicted Reactivity Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Rabbit : 100 %, Rat : 100 %, Mouse : 90 %, Bovine : 80 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against LMNB1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name LMNB1 (LMNB1 Antibody Abstract)
Background LAMNB1 encodes for one of the two B type proteins of the nuclear lamina, B1. The Vertebrate lamins consist of two types, A and B. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.
Molecular Weight 66 kDa
Gene ID 4001
NCBI Accession NP_005564, NM_005573
UniProt P20700
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 586 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Lamin B1 antibody (LMNB1) (Middle Region) (ABIN502713) WB Suggested Anti-LMNB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Product cited in: Lee, Seng, Sekine et al.: "Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1." in: PLoS medicine, Vol. 4, Issue 6, pp. e186, 2007 (PubMed).

Catalog No. ABIN502713
$289.00
Plus shipping costs $45.00

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