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Protocadherin alpha Subfamily C, 1 (PCDHAC1) (N-Term) antibody

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Antigen
Synonyms PCDH-ALPHA-C1, CNRc1, rCNRvc1
Epitope
N-Term
(3)
Reactivity
Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(18), (17), (17)
Host
Rabbit
(18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(11), (8), (3), (2), (2)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human PCDHAC1
Blocking Peptide Blocking peptide for this product available: ABIN981454
Sequence RVQALDPDEG SNGEVQYSLS NSTQAELRHR FHVHPKSGEV QVAASLGPPE
Predicted Reactivity Human : 100 %, Mouse : 100 %, Rat : 100 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against PCDHAC1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCDHAC1 (PCDHAC1 Antibody Abstract)
Background PCDHAC1 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Molecular Weight 87 kDa
Gene ID 56135
NCBI Accession NM_031882, NP_114088
UniProt B2RNA7
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 818 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Protocadherin alpha Subfamily C, 1 (PCDHAC1) (N-Term) antibody (ABIN503031) anti-Protocadherin alpha Subfamily C, 1 (PCDHAC1) (N-Term) antibody
Background publications Wu, Zhang, Cheng et al.: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

Catalog No. ABIN503031
$289.00
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