PCDHA6 antibody (C-Term)

Catalog No. ABIN503116

Product Details anti-PCDHA6 Antibody

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHA6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LVKDHGEPAL TATATVLVSL VESGQAPKAS SRASVGAAGP EAALVDVNVY

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHA6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 803 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHA6

Target: PCDHA6 (Protocadherin alpha 6 (PCDHA6))

Alternative Name: PCDHA6 (PCDHA6 Products)

Synonyms: CNR2 antibody, CNRN2 antibody, CNRS2 antibody, CRNR2 antibody, PCDH-ALPHA6 antibody, CNR antibody, Cnr2 antibody, Crnr2 antibody, rCNRv06 antibody, PCDHA3 antibody, PCDHA6 antibody, PCDHA7 antibody, PCDHA9 antibody, protocadherin alpha 6 antibody, PCDHA6 antibody, Pcdha6 antibody

Background: PCDHA6 contains 6 cadherin domains. It is a potential calcium-dependent cell-adhesion protein. PCDHA6 may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6
Protein Interaction Partner: CUL3, UBC, RELN,
Protein Size: 803

Molecular Weight: 84 kDa

Gene ID: 56142

NCBI Accession: NM_031848, NP_114036