Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

TAB1 antibody (N-Term)

TAB1 Reactivity: Human, Mouse, Rat, Pig, Dog, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN503445
  • Target See all TAB1 Antibodies
    TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
    Binding Specificity
    • 15
    • 15
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 94
    • 41
    • 28
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Pig, Dog, Rabbit, Guinea Pig
    Host
    • 98
    • 9
    • 2
    Rabbit
    Clonality
    • 101
    • 8
    Polyclonal
    Conjugate
    • 42
    • 9
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This TAB1 antibody is un-conjugated
    Application
    • 70
    • 48
    • 26
    • 26
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
    Predicted Reactivity
    Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against MAP3K7IP1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1
    Top Product
    Discover our top product TAB1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 462 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
    Alternative Name
    MAP3K7IP1 (TAB1 Products)
    Synonyms
    3'-Tab1 antibody, MAP3K7IP1 antibody, 2310012M03Rik antibody, Map3k7ip1 antibody, b2b449Clo antibody, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody, TAB1 antibody, Tab1 antibody
    Background
    The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
    Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1
    Protein Interaction Partner: MAGED1, BAG2, MAP3K7, TIRAP, MDM2, SLMAP, NPM1, BIRC3, TRIP6, PPP2R1A, PPP2CB, GRB2, FN1, CDK5RAP3, TAB2, CORO1A, WTAP, MAPK8IP1, UBC, MAPK14, BST2, MAPK12, HSP90AA1, NOTCH1, IKBKB, GRK5, EGFR, STE11, BIRC7, NAIP, XIAP, OGT, TAB3, NR2C2, ARRB2, ARAP1, ACA
    Protein Size: 462
    Molecular Weight
    50 kDa
    Gene ID
    10454
    NCBI Accession
    NM_153497, NP_705717
    UniProt
    Q8IZW2
    Pathways
    TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
You are here:
Support