SOCS7 antibody (N-Term)

Catalog No. ABIN503493

Product Details anti-SOCS7 Antibody

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP

Predicted Reactivity: Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 581 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7 (SOCS7 Products)

Synonyms: NAP4 antibody, NCKAP4 antibody, SOCS4 antibody, SOCS6 antibody, 2310063P06Rik antibody, C85125 antibody, Nap4 antibody, GB13951 antibody, zgc:175115 antibody, SOCS7 antibody, socs7 antibody, suppressor of cytokine signaling 7 antibody, suppressor of cytokine signaling antibody, SOCS7 antibody, Socs7 antibody, LOC413772 antibody, socs7 antibody

Background: SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 581

Molecular Weight: 64 kDa

Gene ID: 30837

NCBI Accession: NM_014598, NP_055413

UniProt: O14512