Tyrosine-Protein Kinase JAK3 (JAK3) (Middle Region) antibody

Details for Product No. ABIN503512
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Antigen
Synonyms JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, fae, wil, RATJAK3, JAK
Epitope
Middle Region
(17), (12), (12), (6), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Pig (Porcine), Dog (Canine), Human, Chicken
(78), (60), (48), (36), (36), (24)
Host
Rabbit
(61), (19)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(44), (30), (28), (13), (13), (10), (9), (7), (4), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN503512
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human JAK3
Sequence KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF
Predicted Reactivity Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Dog : 90 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name JAK3
Background JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
Molecular Weight 125 kDa
Gene ID 3718
NCBI Accession NP_000206, NM_000215
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1124 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Tyrosine-Protein Kinase JAK3 (JAK3) (Middle Region) antibody WB Suggested Anti-JAK3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Small Intestine
Background publications Cheng, Ross, Frost et al.: "Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2271-82, 2008 (PubMed).

Validation Images
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