anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (Middle Region)

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Antigen
Synonyms JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, fae, wil, RATJAK3, JAK
Alternatives
Epitope
Middle Region
(15), (15), (13), (13), (12), (8), (8), (7), (7), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(90), (61), (44), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(72), (23)
Clonality
Polyclonal
Conjugate
This JAK3 antibody is un-conjugated
(3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(58), (43), (24), (17), (14), (12), (9), (9), (4), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human JAK3
Blocking Peptide Blocking peptide for this product available: Tyrosine-Protein Kinase JAK3 (JAK3) (Middle Region) peptide (ABIN978683)
Sequence KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF
Predicted Reactivity Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Dog : 90 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name JAK3 (JAK3 Antibody Abstract)
Background JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
Molecular Weight 125 kDa
Gene ID 3718
NCBI Accession NP_000206, NM_000215
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1124 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (Middle Region) (ABIN503512) WB Suggested Anti-JAK3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Cheng, Ross, Frost et al.: "Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2271-82, 2008 (PubMed).

Catalog No. ABIN503512
$289.00
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