Lymphocyte Cytosolic Protein 1 (LCP1) (N-Term) antibody

Details for Product No. ABIN503551
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Antigen
Synonyms cb245, fj24b12, wu:fj24b12, AW536232, D14Ertd310e, LCP-1, Pls2, pp65, CP64, L-PLASTIN, LC64P, LPL, PLS2, cp64, l-plastin, lc64p, lpl, pls2, plastin-2, 5730589K01Rik, A630040M18, AA410149, LCP1
Epitope
N-Term
(7), (7), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
(40), (21), (17), (17), (13), (12), (12), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(51), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(45), (20), (15), (14), (10), (8), (4), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN503551
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human LCP1
Sequence FIKIFHGLKS TDVAKTFRKA INKKEGICAI GGTSEQSSVG TQHSYSEEEK
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, African clawed frog : 90 %, Chicken : 90 %, Rabbit : 90 %
Characteristics This is a rabbit polyclonal antibody against LCP1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name LCP1
Background Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The L isoform is expressed only in hemopoietic cell lineages. However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
Molecular Weight 70 kDa
Gene ID 3936
NCBI Accession NP_002289, NM_002298
UniProt P13796
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 627 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Lymphocyte Cytosolic Protein 1 (LCP1) (N-Term) antibody WB Suggested Anti-LCP1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
Background publications Klemke, Rafael, Wabnitz et al.: "Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells." in: International journal of cancer. Journal international du cancer, Vol. 120, Issue 12, pp. 2590-9, 2007 (PubMed).

Validation Images
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