Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) (Middle Region) antibody

Details for Product No. ABIN503565
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Antigen
Synonyms 75kDa, AW260155, INPP5P, 5PTase
Epitope
Middle Region
(7), (6), (3), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(16), (4), (3)
Host
Rabbit
(14), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(16), (9), (8), (7), (3), (2)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN503565
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human INPP5B
Sequence IHNGQVPCHF EFINKPDEES YCKQWLNANP SRGFLLPDSD VEIDLELFVN
Predicted Reactivity Guinea pig : 92 %, Mouse : 92 %, Pig : 92 %, Horse : 92 %, Rat : 92 %, Dog : 82 %, Rabbit : 72 %
Characteristics This is a rabbit polyclonal antibody against INPP5B. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name INPP5B
Background Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B is the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus.Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Molecular Weight 77 kDa
Gene ID 3633
NCBI Accession NP_005531, NM_005540
UniProt P32019
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 913 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) (Middle Region) antibody WB Suggested Anti-INPP5B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Hela cell lysate
Product cited in: Tothova, Kollipara, Huntly et al.: "FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress." in: Cell, Vol. 128, Issue 2, pp. 325-39, 2007 (PubMed).

Background publications Dwyer: "Cell surface saccharides of Trypanosoma lewis i. II. Lectin-mediated agglutination and fine-structure cytochemical detection of lectin-binding sites." in: Journal of cell science, Vol. 22, Issue 1, pp. 1-19, 1976 (PubMed).

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