Origin Recognition Complex, Subunit 6 (ORC6) (C-Term) antibody

Details for Product No. ABIN503629
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Antigen
Synonyms
Orc6l, CG1584, DmORC 6, DmORC6, Dmel\\CG1584, ORC, ORC6, orc6, rDmORC, ORC6L, ARABIDOPSIS THALIANA ORIGIN RECOGNITION COMPLEX PROTEIN 6, ATORC6, ORIGIN RECOGNITION COMPLEX SUBUNIT 6, T2P11.3, T2P11_3, ... show more
Orc6l, CG1584, DmORC 6, DmORC6, Dmel\\CG1584, ORC, ORC6, orc6, rDmORC, ORC6L, ARABIDOPSIS THALIANA ORIGIN RECOGNITION COMPLEX PROTEIN 6, ATORC6, ORIGIN RECOGNITION COMPLEX SUBUNIT 6, T2P11.3, T2P11_3, origin recognition complex protein 6, DDBDRAFT_0186183, DDBDRAFT_0233113, DDB_0186183, DDB_0233113, LOC100284755, orc6l, 6720420I10Rik show less
Epitope
C-Term
(7), (4), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Dog (Canine), Cow (Bovine), Human
(30), (3), (3)
Host
Rabbit
(17), (6), (4), (4)
Clonality
Polyclonal
Application
Western Blotting (WB)
(27), (12), (6), (5), (3), (3), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503629
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human ORC6L
Sequence VEAPAKEMEK VEEMPHKPQK DEDLTQDYEE WKRKILENAA SAQKATAE
Predicted Reactivity Dog :100 %,   Bovine :100 %,   Mouse :100 %,   Human :100 %,  
Characteristics This is a rabbit polyclonal antibody against ORC6L. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ORC6L
Background The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Molecular Weight 28 kDa
Gene ID 23594
NCBI Accession NP_055136, NM_014321
UniProt Q9Y5N6
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 252 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Origin Recognition Complex, Subunit 6 (ORC6) (C-Term) antibody WB Suggested Anti-ORC6L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human Liver
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Validation Images
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