AKT Interacting Protein (AKTIP) (Middle Region) antibody

Details for Product No. ABIN503874
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Synonyms FTS, fts, cb798, zgc:77699, aktip, fts-B, FT1, Fts, MGC133931, AL023020, Fif, Ft, Ft1
Middle Region
(15), (15), (12), (6), (3), (2), (2), (1), (1), (1), (1)
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(57), (21), (18), (1), (1), (1), (1), (1)
(46), (11)
(5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(41), (23), (10), (3), (3), (3)
Pubmed 1 reference available
Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the middle region of human AKTIP
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name AKTIP (AKTIP Antibody Abstract)
Background AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Molecular Weight 33 kDa
Gene ID 64400
NCBI Accession NP_001012398, NM_001012398
UniProt Q9H8T0
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 292 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-AKT Interacting Protein (AKTIP) (Middle Region) antibody (ABIN503874) WB Suggested Anti-AKTIP Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Product cited in: Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: , Vol. 3, pp. 89, 2007 (PubMed).

Catalog No. ABIN503874
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