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Details for Product No. ABIN504421

Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) antibody

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Antigen
Synonyms AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, Cbfa2t1h, Cbfa2t1, si:ch211-232j17.1, wu:fi14b07, zgc:154044
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio), Xenopus laevis, Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN504421
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-RUNX1T1 antibody: synthetic peptide directed towards the middle region of human RUNX1T1
Sequence RQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREES LLGAPSESHA
Predicted Reactivity Dog : 100%, Human : 100%, Pig : 100%, African clawed frog : 92%, Chicken : 92%, Horse : 92%, Mouse : 92%, Zebrafish : 92%, Rat : 85%
Characteristics This is a rabbit polyclonal antibody against RUNX1T1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name RUNX1T1
Background RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Molecular Weight 64kDa
Gene ID 862
NCBI Accession NP_004340, NM_004349
UniProt B2R6I9
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-RUNX1T1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Salat, Liefke, Wiedenmann et al.: "ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3502-12, 2008 (PubMed).

Alternatives for antigen "Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1)", type "Antibodies"
Hosts (25), (6)
Reactivities (30), (18), (16), (14), (14), (12), (2), (2)
Applications (22), (11), (10), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (2), (1)
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