Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) antibody

Details for Product No. ABIN504421
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Antigen
Synonyms MTG8, si:ch211-232j17.1, wu:fi14b07, zgc:154044, AML1T1, CBFA2T1, CDR, ETO, ZMYND2, Cbfa2t1h, Cbfa2t1
Epitope
Middle Region
(2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio), Xenopus laevis, Human, Chicken
(33), (19), (17), (14), (14), (12), (2), (2)
Host
Rabbit
(28), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(25), (10), (8), (3), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN504421
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human RUNX1T1
Sequence RQCNLQQFIQ QTGAALPPPP RPDRGPPGTQ GPLPPAREES LLGAPSESHA
Predicted Reactivity Dog : 100 %, Human : 100 %, Pig : 100 %, African clawed frog : 90 %, Chicken : 90 %, Horse : 90 %, Mouse : 90 %, Zebrafish : 90 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against RUNX1T1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RUNX1T1
Background RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Molecular Weight 64 kDa
Gene ID 862
NCBI Accession NM_004349, NP_004340
UniProt B2R6I9
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 577 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) antibody WB Suggested Anti-RUNX1T1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate
Background publications Salat, Liefke, Wiedenmann et al.: "ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3502-12, 2008 (PubMed).

Validation Images
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