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Details for Product No. ABIN504441

Adrenocortical Dysplasia Homolog (Mouse) (ACD) (C-Term) antibody

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Antigen
Synonyms PIP1, PTOP, TPP1, TINT1, ACD
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN504441
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-ACD antibody: synthetic peptide directed towards the C terminal of human ACD
Sequence SSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPR SHVPSPHQAL
Predicted Reactivity Human : 100%
Characteristics This is a rabbit polyclonal antibody against ACD. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name ACD
Background ACD is a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere.This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
Molecular Weight 58kDa
Gene ID 65057
NCBI Accession NP_001075955, NM_001082486
UniProt Q96AP0
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-ACD antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Hockemeyer, Palm, Else et al.: "Telomere protection by mammalian Pot1 requires interaction with Tpp1." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 754-61, 2007 (PubMed).

Alternatives for antigen "Adrenocortical Dysplasia Homolog (Mouse) (ACD)", type "Antibodies"
Hosts (37), (9)
Reactivities (40), (28), (24), (23), (23), (11)
Applications (27), (19), (14), (10), (6), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (4), (4), (2), (1), (1)
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