Adrenocortical Dysplasia Homolog (Mouse) (ACD) (C-Term) antibody

Details for Product No. ABIN504441
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Antigen
Synonyms PIP1, PTOP, TPP1, TINT1, ACD
Epitope
C-Term
(5), (4), (2), (1), (1)
Reactivity
Human
(46), (28), (24), (23), (23), (11)
Host
Rabbit
(42), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(33), (19), (13), (9), (7), (6), (3), (1)
Pubmed 1 reference available
Catalog no. ABIN504441
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the C terminal of human ACD
Sequence SSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPR SHVPSPHQAL
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against ACD. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ACD
Background ACD is a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere.This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
Molecular Weight 58 kDa
Gene ID 65057
NCBI Accession NM_001082486, NP_001075955
UniProt Q96AP0
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 544 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Adrenocortical Dysplasia Homolog (Mouse) (ACD) (C-Term) antibody WB Suggested Anti-ACD Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain
Background publications Hockemeyer, Palm, Else et al.: "Telomere protection by mammalian Pot1 requires interaction with Tpp1." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 754-61, 2007 (PubMed).

Hosts (42), (10)
Reactivities (46), (28), (24), (23), (23), (11)
Applications (33), (19), (13), (9), (7), (6), (3), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (5), (4), (2), (1), (1)
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