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Details for Product No. ABIN504443

Centromere Protein H (CENPH) (Middle Region) antibody

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Antigen
Synonyms ENP, CENP-H, AU044255, 1700021I11Rik, 2410018A12Rik, 2610042E16Rik, 2810046K12Rik, si:dkey-186m8.3, cenp-h
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Mouse (Murine), Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN504443
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-CENPH antibody: synthetic peptide directed towards the middle region of human CENPH
Sequence ESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKID LDSMENSERI
Predicted Reactivity Horse : 100%, Human : 100%, Bovine : 92%, Mouse : 92%, Dog : 78%
Characteristics This is a rabbit polyclonal antibody against CENPH. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name CENPH
Background Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. CENPH colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
Molecular Weight 27kDa
Gene ID 64946
NCBI Accession NP_075060, NM_022909
UniProt Q9H3R5
Research Area Cancer, Cell Cycle
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-CENPH antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Product cited in: Liao, Zhang, Zhou et al.: "Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity." in: Cancer research, Vol. 67, Issue 17, pp. 8131-8, 2007 (PubMed).

Background publications Liao, Song, Zhang et al.: "Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 2 Pt 1, pp. 508-14, 2007 (PubMed).

Alternatives for antigen "Centromere Protein H (CENPH)", type "Antibodies"
Hosts (26), (17)
Reactivities (41), (18), (16), (12), (12)
Applications (33), (11), (10), (8), (6), (5), (5), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (2), (2), (1), (1)
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